Enzyme-Inhibitor-Like Tuning of Calcium Channel Connectivity With Calmodulin
نویسندگان
چکیده
منابع مشابه
Calmodulin and calcium channel blockers.
IONIZED calcium regulates many cellular processes, such as cell motility, muscle contraction, axonal flow, cytoplasmic streaming, neurotransmitter release, endocytosis, andexocytosis. Intracellular Ca concentrations under steady state conditions are low, usually below 10" M. Upon stimulation, the Ca concentration increases transiently and apparently signals an appropriate response, which is oft...
متن کاملThe interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors.
The calmodulin inhibitors R24571 and trifluoperazine were found to inhibit competitively the binding of [3H]nitrendipine to a 48,000 X g particulate fraction of rat brain with IC50 values of 1.0 and 18.8 microM, respectively. Equilibrium dialysis was used to test the ability of the dihydropyridines nitrendipine, felodipine, and nicardipine to inhibit the binding of [3H]chlorpromazine, [14C]pimo...
متن کاملComparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury.
The protective effect of converting enzyme inhibitors in experimental hypertensive glomerular injury is associated with decreased systemic arterial and glomerular capillary pressure. Although calcium channel blockers effectively lower systemic blood pressure, their effect on glomerular capillary pressure and on hypertensive glomerular injury is uncertain. We compared equihypotensive treatment w...
متن کاملTuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent
Calmodulin (CaM) is a ubiquitous intracellular protein that regulates biological activities of numerous enzymes and ion channels. Upon responding Ca concentration change, Cadependent CaM activates the hydrolyzation of cGMP by PDE and Ca releasing channel activity of ryanodine receptor. In this dissertation, a series of CaM variants were engineered to enhance Ca binding affinities by increasing ...
متن کاملChimeric plant calcium/calmodulin-dependent protein kinase gene with a neural visinin-like calcium-binding domain.
Calcium, a universal second messenger, regulates diverse cellular processes in eukaryotes. Ca2+ and Ca2+/calmodulin-regulated protein phosphorylation play a pivotal role in amplifying and diversifying the action of Ca(2+)-binding domain was cloned and characterized from lily. The cDNA clone contains an open reading frame coding for a protein of 520 amino acids. The predicted structure of CCaMK ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.12.098